Numoisyn™ Liquid and Lozenges for the treatment of xerostomia Relief for Xerostomia Sufferers

Numoisyn™ Lozenges—Numoisyn™ Lozenges dissolve slowly while moved around in the mouth. They contain sorbitol and malic acid to stimulate normal salivation and provide temporary relief of dry mouth in patients who have some residual secretory function and taste perception. Numoisyn™ Lozenges support saliva’s natural protection of teeth so that teeth are not damaged with repeated use of the lozenges(*1). They are sugar free and buffered with calcium to protect teeth. Numoisyn™ Lozenges have been demonstrated to be safe and effective for long-term use and are well tolerated by patients(*1). Use of Numoisyn™ Lozenges improves subjective symptoms of dry mouth(*2) and does not cause bacteria or plaque formation or loss of tooth enamel hardness(*3).

Pharmacological agents, usually cholinergic agonists, trigger secretory function. Alternatively, saliva secretion may be increased with bitter-tasting substances or mechanical stimulation, such as chewing sugar-free gum or sucking sugar-free sweets. Numoisyn™ Lozenges increase salivary secretion by stimulating gustatory (taste) pathways. Additionally, Numoisyn™ Lozenges can be used as a diagnostic tool to evaluate salivary function.

Numoisyn™ Liquid—Numoisyn™ Liquid is an oral solution used to replace natural saliva when salivary glands are damaged. The viscosity of Numoisyn™ Liquid is similar to that of natural saliva. Linseed extract in Numoisyn™ Liquid contains mucins that provide superior viscosity and reduced friction compared to water or carboxymethylcellulose (CMC) solutions(*4). In fact, linseed extract significantly reduces the symptoms of dry mouth, an effect that increases over time while Numoisyn™ Liquid is used(*4).

Patients with xerostomia typically have a high number of acid-tolerant microorganisms (eg, lactobacilli, mutans streptococci, yeast) that contribute to plaque and gingival bleeding. Numoisyn™ Liquid reduces the presence of plaque and gingival bleeding to a greater extent than CMC(*4), and it can be used in conjunction with chlorhexidine without impairing the antibacterial effects of chlorhexidine(*5).

From a practical viewpoint, the duration of the effect of Numoisyn™ Liquid is approximately twice that of CMC(*4), and patients require about three times as much volume of CMC compared to the volume required for a similar dose of Numoisyn™ Liquid. Numoisyn™ Liquid is well-tolerated by patients and most patients experience and improvement in chewing, swallowing and burning sensation (*6).

Although patients frequently sip water to relieve the symptom of dry mouth, water does not have the protective effects associated with the many other components of saliva. Saliva substitute preparations provide longer-lasting relief than water because they increase viscosity and lubrication of oral fluid. In addition, Numoisyn Liquid™ forms a film on hard and soft surfaces to protect teeth and gums (*7).

Please refer to the Package Insert for Lozenges or Package Insert for Liquid for specific product and prescribing information.

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References: 1. Axelsson P, Larsson, U-B. The saliva stimulating tablet SST in long-term clinical trial. Tandlakartidningen. 1991;83:698- 699. 2. Data on file, Align Pharmaceuticals. 3. Data on file, Align Pharmaceuticals. 4. Andersson G, Johansson G, Attstrom R, Edwardsson S, Glantz P-O, Larsson K. Comparison of the effect of the linseed extract Salinum ® and a methyl cellulose preparation on the symptoms of dry mouth. Gerodontology. 1995;12:12-17. 5. Johansson G, Andersson G, Edwardsson S, et al. Effects of mouthrinses with linseed extract Salinum without/with chlorhexidine on oral conditions in patients with Sjögren’s syndrome: A double-blind crossover investigation Gerodontology. 2001;18(2):87-94 6. Johansson G, Andersson G, Attstrom R, Glantz P-O, Larsson K. The effect of Salinum on the symptoms of dry mouth: a pilot study. Gerodontology. 1994;11:46-49. 7. Christersson CE, Lindh L, Arnebrant T. Film-forming properties and viscosities of saliva substitutes and human whole saliva. Eur J Oral Sci. 2000;108:418-425.